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R)-21.8 (a)-19 (t E)-23.3 (C)-26.6 (G a)-11.3 (n)-17 (d r)-21.8 (e)-19.9 (s)-12.4 (p)-9.7 (i)-1.7 (r)-26 (a)-19 (t)-15.7 (i)-4.2 (o)-16.1 (n t)-23.2 (r)-26 (a)-15.9 (c)-20.9 (e)-19.9 (s o)-13.9 (b)-24.5 (t)-30.2 (a)-1.6 (i)-3.5 (n)-15.2 (e)-20.9 (d f)-24.6 (r)-21.8 (o)-16.6 (m S)-27 (A i)-3.5 (n)-13.9 (s)-26 (t)-23.2 (r)-26.5 (u)-12.4 (m)-16.2 (e)-14.2 (n)-20 (t)-27.9 (s)]TJ 0 0 0 scn /GS0 gs /T1_0 1 Tf 0 Tc 9.25 0 0 9.25 36 302.2794 Tm [(A)-3.3 (f)-25.2 (t)12.4 (e)-2.1 (r p)-7.8 (l)-7 (a)-5.5 (c)-7.6 (e)-2.5 (m)-2.9 (e)-2.1 (n)8.2 (t o)6.3 (f t)-1.4 (h)-1.1 (e e)-1.8 (l)-3.1 (e)-6.6 (c)-11.3 (t)-1.3 (r)8.6 (o)-13 (d)-8.3 (e)-2.3 (s)-4.6 (, t)-1.3 (h)-1.2 (e E)-2.8 (C)-11.5 (G s)0.6 (i)-2.8 (g)-6.2 (n)-6.1 (a)-0.8 (l s)0.8 (h)-4 (o)-4 (u)-0.8 (l)-6.3 (d )]TJ 0 -1.351 TD [(l)-4.7 (o)-11.8 (o)-2.7 (k l)1.6 (i)3.6 (k)22 (e t)-1.4 (h)-1.1 (e o)-4.7 (n)-1.1 (e d)-5.8 (i)-0.6 (s)-4.6 (p)-7.8 (l)-7 (a)3 (y)9.7 (e)-8.7 (d i)0.9 (n f)-1.8 (i)-2.8 (g)-3.8 (u)-1.5 (r)10.6 (e 3)-13.6 (. P)-10.9 (h)9.7 (y)-0.8 (s)0.6 (i)-3.2 (o)-6.1 (l)-4.7 (o)-11.4 (g)-5.8 (i)-2.3 (c)-18.5 (a)-0.8 (l h)-1.1 (e)-8.5 (a)-1.4 (r)-33.8 (t )]TJ 0 -17.189 TD [(r)-4.7 (a)1.6 (t)12.4 (e v)-1.8 (a)-0.8 (l)2 (u)-3.5 (e)-2.3 (s a)-1.4 (r)10.7 (e i)0.9 (n t)-1.4 (h)-1.1 (e o)-4.7 (r)4.4 (d)-8.3 (e)-2.1 (r o)6.3 (f 3)-28.1 (0)-41.7 (0 b)-10.2 (p)-5.9 (m f)13.4 (o)-4.7 (r r)-4.6 (a)1.6 (t)-7.1 (s a)-1.4 (n)-4.6 (d 5)-29.1 (0)-41.7 (0 b)-10.2 (p)-5.9 (m )]TJ 0 -1.351 TD [(f)13.4 (o)-4.7 (r mi)-2.3 (c)-7.5 (e \()-13.3 (N)-15.5 (o)6.7 (t)12.4 (e)20.6 (: T)-20.5 (h)-1.1 (e a)2.1 (u)-4.7 (t)12.5 (o)-5.1 (m)-8 (a)1.6 (t)-0.9 (i)-2.3 (c d)-8.3 (e)7.7 (t)12.4 (e)-6.6 (c)-11.3 (t)-0.9 (i)-3.1 (o)-4.7 (n o)6.3 (f R w)-3.3 (a)5.9 (v)8.2 (e)-2.3 (s o)-4.7 (r i)0.9 (n )]TJ 0 -1.351 TD [(s)-3.7 (o)-5.1 (m)-3 (e s)0.6 (i)-2.7 (t)1.9 (u)-8.5 (a)1.6 (t)-0.8 (i)-3.2 (o)-4.7 (ns w)-9 (i)-2.7 (t)-1.4 (h n)-4 (o)-4.2 (i)-0.6 (s)-0.8 (y E)-2.9 (C)-11.5 (G s)0.7 (i)-2.8 (g)-6.2 (n)-6.1 (a)-0.8 (l m)-8 (a)3 (y l)-3.1 (e)-8.5 (a)-5.6 (d t)12.5 (o e)-2.1 (r)-9 (r)8.6 (o)-4.7 (n)-1.1 (e)-7.6 (o)-4 (u)-2 (s )]TJ T* [(v)-1.8 (a)-0.8 (l)2 (u)-3.5 (e)-2.3 (s)7.3 (\))22.9 (. F)-9.6 (o)-4.7 (r S)-21 (A i)1 (ns)-2.3 (t)-1.3 (r)-6.6 (u)-1.9 (m)-3 (e)-2.1 (n)8.2 (t s)-0.8 (y)-0.8 (s)-2.3 (t)12.4 (e)-2.5 (m)-1.5 (s)-4.6 (, s)-3.7 (o)-5.1 (m)-3 (e u)-2 (s)-0.9 (e)-2.1 (r s)-0.9 (e)7.7 (t)-25.2 (t)-0.9 (i)0.9 (n)-5.1 (g)-6.8 (s m)-8 (a)3 (y )]TJ T* [(n)-1.1 (e)-4.7 (e)-8.7 (d t)12.5 (o b)-10.1 (e v)8.2 (e)-2.1 (r)-6.1 (i)-3.1 (f)-1.9 (ie)-8.7 (d t)12.5 (o e)-2.1 (ns)4.2 (u)-1.5 (r)10.6 (e p)-5.4 (r)8.6 (o)-9.4 (p)-10.1 (e)-2.1 (r g)-13.2 (a)1.6 (t)-0.9 (i)0.9 (n)-5 (g)-5.8 (. I)-2.8 (n t)-1.3 (h)-1.1 (e g)-13.2 (a)1.6 (t)-0.9 (i)0.9 (n)-5.1 (g t)-12.3 (a)-6.2 (b )]TJ T* [(\()-2.4 (fr)8.6 (o)-5.1 (m t)-1.4 (h)-1.1 (e b)-13 (o)6.7 (t)-25.2 (t)12.6 (o)-5.1 (m o)6.3 (f t)-1.4 (h)-1.1 (e E)-2.9 (C)-11.5 (G t)-1.3 (r)-4.7 (a)-5.6 (c)-7.5 (e s)-2.7 (c)-7.5 (r)10.6 (e)-4.7 (e)-2.1 (n)8.2 (\))11.3 (, y)7.3 (o)-4 (u w)-9 (i)1.7 (l)1.9 (l h)-6.1 (a)5.9 (v)8.2 (e )]TJ T* [(a)-5.6 (c)-9.4 (c)-7.5 (e)-2.3 (s)-6.1 (s t)12.5 (o t)-1.4 (h)-1.1 (e c)-9.9 (o)-4.7 (n)8.2 (t)-1.3 (r)8.6 (o)-6.1 (l o)6.3 (f t)-1.4 (h)-1.1 (e g)-13.2 (a)1.6 (t)-0.9 (i)0.9 (n)-5.1 (g)-5.8 (. F)3.8 (r)8.6 (o)-5.1 (m t)-1.4 (h)-1 (e m)-8 (a)-1 (i)0.9 (n g)-13.2 (a)1.6 (t)-0.9 (i)0.9 (n)-5.1 (g )]TJ T* [(w)-9 (i)0.9 (n)-4.6 (d)-9.4 (o)4.9 (w \()-10.5 (g)-13.2 (a)1.6 (t)-0.8 (i)0.9 (n)-5.1 (g s)-0.9 (e)7.7 (t)1.9 (u)-6.2 (p f)13.4 (o)-4.7 (r)-9.5 (m)6.3 (\))11.3 (, o)-4.7 (n)-1.1 (e c)-18.5 (a)-1.4 (n s)-0.9 (e)-1.8 (l)-3.1 (e)-6.6 (c)-11.3 (t t)-1.3 (h)-1.1 (e c)-6.8 (h)-6.1 (a)-1.4 (n)1.8 (n)-1.1 (e)-1.8 (l)-0.6 (s t)12.5 (o )]TJ 28.898 72.741 Td [(b)-10.1 (e u)-2 (s)-0.9 (e)-8.7 (d f)13.4 (o)-4.7 (r g)-13.2 (a)1.6 (t)-0.9 (i)1 (n)-5.2 (g \()-8.5 (E)-2.9 (C)-11.5 (G w)-9 (i)1.7 (l)1.9 (l n)-1.1 (e)-4.6 (e)-8.7 (d t)12.5 (o b)-10.1 (e s)-0.9 (e)-1.8 (l)-3.1 (e)-6.6 (c)-11.3 (t)12.4 (e)-8.7 (d f)13.4 (o)-4.7 (r c)-18.5 (a)-1.4 (r)4.4 (d)-5.8 (i)-5.3 (a)-5.6 (c )]TJ T* [(g)-13.2 (a)1.6 (t)-0.9 (i)0.9 (n)-5.1 (g)-2.8 (\) a)-1.4 (n)-4.6 (d b)-11.4 (a)-2 (s)0.6 (i)-2.3 (c p)-11.4 (a)-1.4 (r)-4.6 (a)-1.9 (m)-3 (e)7.7 (t)12.4 (e)-2.1 (r)-5.6 (s c)-18.5 (a)-1.4 (n b)-10.1 (e c)-9.9 (o)-4.7 (n)8.2 (t)-1.3 (r)8.6 (o)-6.1 (l)1.9 (l)-3 (e)-8.8 (d)-10.1 (, s)4.2 (u)-5.4 (c)-6.9 (h a)-2 (s t)-1.4 (h)-1.1 (e )]TJ T* [(d)-8.3 (e)-1.8 (l)-7 (a)3 (y fr)8.6 (o)-5.1 (m t)-1.3 (h)-1.1 (e d)-8.3 (e)7.7 (t)12.4 (e)-6.6 (c)-11.3 (t)-0.9 (i)-3.2 (o)-4.7 (n o)6.3 (f t)-1.4 (h)-1.1 (e R w)-3.3 (a)5.9 (v)8.2 (e a)-1.4 (n)-4.6 (d t)-1.3 (h)-1.1 (e d)-3 (u)-1.5 (r)-4.7 (a)1.6 (t)-0.9 (i)-3.2 (o)-4.7 (n f)13.4 (o)-4.7 (r )]TJ 0 -1.351 TD [(w)-9.5 (h)2.3 (i)-2.3 (c)-6.8 (h t)-1.4 (h)-1.1 (e g)-13.2 (a)1.6 (t)12.4 (e w)-8.9 (i)1.7 (l)1.9 (l b)-10.1 (e o)-9.4 (p)-10.1 (e)-2.1 (n \()-10.9 (M)-18 (a)-11.8 (x w)-9 (i)-3.9 (d)-9.4 (t)-1.4 (h)8.2 (\))22.9 (. T)-20.5 (h)-1.1 (e w)-9.5 (h)2.3 (i)-2.7 (t)12.4 (e b)-11.4 (a)-1.4 (r fr)8.6 (o)-5.1 (m )]TJ 0 -1.351 TD [(t)-1.4 (h)-1.1 (e m)-5.9 (o)-4.7 (n)2.3 (i)-2.7 (t)12.6 (o)-4.8 (r)-6 (i)0.9 (n)-5.1 (g t)-1.3 (r)-4.7 (a)-5.6 (c)-7.5 (e w)-9 (i)0.9 (n)-4.6 (d)-9.4 (o)4.9 (w \()-2.4 (f)-1.8 (i)-2.7 (g 3)-11.6 (\) c)-9.9 (o)-4.7 (r)-9 (r)10.6 (e)-2.3 (s)-4.6 (p)-13 (o)-4.7 (n)-4.6 (d t)12.5 (o t)-1.4 (h)-1.1 (e g)-13.2 (a)1.6 (t)12.4 (e )]TJ T* [(d)-8.3 (e)7.7 (t)12.4 (e)-6.6 (c)-11.3 (t)-0.9 (i)-3.2 (o)-4.7 (n a)-1.4 (n)-4.6 (d g)-13.2 (a)1.6 (t)12.5 (e l)-3.1 (e)-2.1 (n)-5.1 (g)-11.8 (t)-1.4 (h)-2.2 (. T)-20.5 (h)-1.1 (e r)10.6 (e)-8.7 (d b)-11.4 (a)-1.4 (r)-5.6 (s c)-9.9 (o)-4.7 (r)-9 (r)10.6 (e)-2.3 (s)-4.6 (p)-13 (o)-4.7 (n)-4.6 (d t)12.6 (o t)-1.4 (h)-1.1 (e )]TJ T* [(d)-3 (u)-1.5 (r)-4.7 (a)1.6 (t)-0.9 (i)-3.2 (o)-4.7 (n o)6.3 (f t)-1.4 (h)-1.1 (e b)-7.8 (l)-7 (a)-1.4 (n)3.1 (k)-8.4 (i)0.9 (n)-5.1 (g p)-10.1 (e)-2.1 (r)-6.1 (i)-3.2 (o)-13 (d)-7.4 (. F)-9.6 (o)-4.7 (r f)2.1 (u)-1.6 (r)-33.7 (t)-1.4 (h)-1.1 (e)-2.1 (r c)-9.9 (o)-4.7 (n)8.2 (t)-1.3 (r)8.6 (o)-6.1 (l o)6.3 (f t)-1.4 (h)-1.1 (e R )]TJ T* [(w)-3.3 (a)5.9 (v)8.2 (e d)-8.3 (e)7.7 (t)12.4 (e)-6.6 (c)-11.3 (t)-0.9 (i)-3.1 (o)-4.8 (n)-3 (, y)7.2 (o)-3.9 (u c)-18.5 (a)-1.5 (n c)-7.4 (l)1.6 (i)-2.3 (c)-3.9 (k o)-4.7 (n t)-1.4 (h)-1.1 (e E)-2.9 (C)-11.5 (G b)-4.6 (u)-4.7 (t)-25.2 (t)12.6 (o)-4.7 (n o)-4.7 (r r)-6.1 (i)-2.8 (g)-6.1 (h)8.2 (t c)-7.4 (l)1.6 (i)-2.3 (c)-3.9 (k )]TJ T* [(o)-4.7 (n t)-1.4 (h)-1.1 (e E)-2.9 (C)-11.5 (G w)-3.2 (a)5.9 (v)8.1 (e)7.3 (f)13.4 (o)-4.7 (r)-9.5 (m)-4.1 (.)]TJ 0 -2.271 TD [(O)-11.1 (n)-1.1 (e o)6.3 (f t)-1.4 (h)-1.1 (e k)22 (e)5.8 (y s)-0.9 (e)7.7 (t)-25.2 (t)-0.8 (i)0.9 (n)-5.1 (g i)-0.6 (s t)12.5 (o u)-2 (s)-0.9 (e a b)-7.8 (l)-7 (a)-1.4 (n)3.1 (k)-8.4 (i)0.9 (n)-5.1 (g p)-10.1 (e)-2.1 (r)-6.1 (i)-3.1 (o)-13 (d t)-1.4 (h)-6.1 (a)1.6 (t )]TJ 0 -1.351 TD [(c)-9.9 (o)6.2 (v)8.2 (e)-2.1 (r)-5.6 (s m)-5.9 (o)-3.3 (s)-2.3 (t o)6.3 (f t)-1.4 (h)-1.1 (e c)-18.4 (a)-1.5 (r)4.5 (d)-5.8 (i)-5.3 (a)-5.6 (c p)-10.1 (e)-2.1 (r)-6.1 (i)-3.2 (o)-13 (d b)-4.6 (u)-4.7 (t w)-9 (i)-2.7 (t)-1.3 (h s)-3.7 (o)-5.1 (m)-3 (e m)-8 (a)-1.4 (r)3.9 (g)-5.8 (i)0.9 (n t)12.5 (o )]TJ 0 -1.351 TD [(e)-2.1 (n)-6.1 (a)-6.2 (b)-7.8 (l)-3.1 (e d)-8.3 (e)7.7 (t)12.4 (e)-6.6 (c)-11.3 (t)-0.9 (i)-3.1 (o)-4.7 (n o)6.3 (f t)-1.4 (h)-1.1 (e n)-1.1 (e)15 (x)-27.1 (t R)-37.6 (-)-27.3 (w)-3.3 (a)5.9 (v)8.2 (e i)0.9 (n t)-1.4 (h)-1.1 (e v)8.2 (e)-2.1 (n)8.2 (t o)6.3 (f d)-8.3 (e)-6.6 (c)-7.5 (r)10.6 (e)-8.5 (a)-2 (s)-0.9 (e )]TJ T* [(c)-18.5 (a)-1.4 (r)4.4 (d)-5.8 (i)-5.3 (a)-5.6 (c p)-10.1 (e)-2.1 (r)-6.1 (i)-3.2 (o)-13 (d d)-3 (u)-1.5 (r)-6.1 (i)0.9 (n)-5.1 (g t)-1.4 (h)-1.1 (e d)-3 (u)-1.5 (r)-4.7 (a)1.6 (t)-0.9 (i)-3.2 (o)-4.7 (n o)6.3 (f t)-1.3 (h)-1.1 (e P)-12 (E)-31.9 (T s)-2.8 (c)-18.5 (a)-1.4 (n)-2.2 (. T)-20.5 (h)-1.1 (e)-2.1 (n )]TJ T* [(s)-0.9 (e)-1.8 (l)-3.1 (e)-6.6 (c)-11.3 (t p)-13 (o)-3.3 (s)0.6 (i)-2.7 (t)-0.9 (i)-6.9 (v)8.2 (e p)-10.1 (e)-8.5 (a)1.9 (k f)13.4 (o)-4.7 (r p)-13 (o)-3.3 (s)0.6 (i)-2.7 (t)-0.9 (i)-7 (v)8.2 (e R)-37.6 (-)-27.3 (w)-3.2 (a)5.8 (v)8.3 (e o)-4.7 (r n)-1.1 (e)-7.1 (g)-13.2 (a)1.6 (t)-0.9 (i)-7 (v)8.2 (e p)-10.1 (e)-8.5 (a)1.9 (k )]TJ T* [(f)13.4 (o)-4.7 (r n)-1.1 (e)-7.1 (g)-13.2 (a)1.6 (t)-0.9 (i)-6.9 (v)8.1 (e R)-37.5 (-)-27.3 (w)-3.3 (a)5.9 (v)8.2 (e)3.7 (. I)-2.8 (n t)-1.4 (h)-1.1 (e)-2.3 (s)-0.9 (e s)-0.9 (e)7.7 (t)-25.2 (t)-0.9 (i)0.9 (n)-5.1 (g)-6.8 (s)-4.6 (, t)-1.4 (h)-1.1 (e g)-13.2 (a)1.6 (t)12.4 (e is g)-9.4 (o)-4.2 (i)0.9 (n)-5.1 (g t)12.5 (o )]TJ T* [(b)-10.1 (e g)-8.3 (e)-2.1 (n)-1.1 (e)-2.1 (r)-4.7 (a)1.6 (t)12.4 (e)-8.7 (d j)3.2 (u)-2 (s)-2.3 (t a)1.1 (f)-25.1 (t)12.4 (e)-2.1 (r t)-1.4 (h)-1.1 (e d)-8.3 (e)7.7 (t)12.4 (e)-6.6 (c)-11.3 (t)-0.9 (i)-3.2 (o)-4.7 (n o)6.3 (f t)-1.4 (h)-1 (e R)-37.6 (-)-27.3 (w)-3.3 (a)5.9 (v)8.2 (e \(a)1.1 (f)-25.2 (t)12.4 (e)-2.1 (r )]TJ T* [(c)-7.5 (r)8.6 (o)-3.3 (s)-6.1 (s)0.6 (i)0.9 (n)-5.1 (g t)-1.4 (h)-1.1 (e r)-6.1 (is)0.6 (i)0.9 (n)-5.1 (g a)-1.4 (n)-4.6 (d f)1 (a)-0.8 (l)1.9 (l)1.6 (i)0.9 (n)-5.1 (g v)5.9 (o)-6.1 (l)-2.7 (t)-12.3 (a)-6 (g)-8.3 (e t)-1.4 (h)1.8 (r)10.6 (e)-2.3 (s)0.8 (h)-4 (o)-6.1 (l)-6.3 (d)-10.9 (\))22.9 (. \()-13.3 (N)-15.6 (o)6.7 (t)12.4 (e)20.6 (: )]TJ 0 -1.351 TD [(T)-20.5 (h)-1.1 (e d)-8.3 (e)7.2 (f)1 (a)2.1 (u)-0.8 (l)-2.8 (t i)-0.6 (s 2)-10.1 (0)-41.7 (0 )]TJ /C2_0 1 Tf <0050>Tj /T1_0 1 Tf 8.866 0 Td [(V b)-4.6 (u)-4.7 (t i)-2.7 (t c)-18.5 (a)-1.3 (n b)-10.2 (e a)-5.5 (d)-7 (j)3.2 (u)-2 (s)-2.3 (t)12.4 (e)-8.7 (d d)-8.3 (e)-6.8 (p)-10.1 (e)-2.1 (n)-4.6 (d)-5.8 (i)0.9 (n)-5.1 (g t)-1.4 (h)-1.1 (e )]TJ -8.866 -1.351 Td [(a)-1.9 (m)-4.9 (p)-7.8 (l)1.6 (i)-2.7 (t)1.9 (u)-5.3 (d)-8.4 (e o)6.3 (f t)-1.4 (h)-1.1 (e E)-2.9 (C)-11.5 (G s)0.6 (i)-2.8 (g)-6.2 (n)-6.1 (a)-0.8 (l)-4.3 (\))22.9 (. 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A t)12.4 (e)-6.6 (c)-6.8 (h)1.8 (n)2.3 (i)-2.3 (c)-18.5 (a)-0.8 (l d)-8.3 (e)-2.3 (s)-2.8 (c)-7.5 (r)-6.1 (i)-3.8 (p)2.4 (t)-0.8 (i)-3.2 (o)-4.7 (n o)-4.7 (n t)-1.4 (h)-1.1 (e n)-1.1 (e)7.2 (w )]TJ 0 -1.351 TD [(B)-2.5 (r)-6.6 (u)1.6 (k)22 (e)-2.1 (r P)-12 (E)-31.8 (T d)-8.2 (e)-2.3 (s)0.5 (i)-2.7 (g)-6.2 (n a)-1.4 (n)-4.6 (d p)-10.1 (e)-2.1 (r)-34.3 (f)13.4 (o)-4.7 (r)-9.5 (m)-8 (a)-1.4 (n)-4.6 (c)-7.5 (e c)-18.5 (a)-1.4 (n b)-10.1 (e f)13.4 (o)-4 (u)-1.5 (n)-4.6 (d i)0.9 (n r)10.6 (e)7.2 (f)33.5 (. )]TJ T* [(1)46.4 (. T)-20.5 (h)-1.1 (e im)-4.9 (p)-11.4 (a)-5.6 (c)-11.3 (t o)6.3 (f B)-2.4 (r)-6.6 (u)1.6 (k)22 (e)-2.1 (r)-17.6 (\222)38.2 (s n)-1.1 (e)7.2 (w P)-12 (E)-31.9 (T t)12.4 (e)-6.6 (c)-6.8 (h)1.8 (n)-4 (o)-6.1 (l)-4.7 (o)-11.4 (g)-19 (y i)0.9 (n c)-18.5 (a)-1.4 (r)4.4 (d)-5.8 (i)-5.3 (a)-5.6 (c )]TJ T* [(im)-8 (a)-6 (g)-5.8 (i)0.9 (n)-5.1 (g h)-6.1 (a)-2 (s b)-10 (e)-4.7 (e)-2.2 (n d)-5.8 (is)-2.8 (c)-3.4 (u)-2 (s)-6.1 (s)-0.9 (e)-8.7 (d i)0.9 (n t)-1.4 (h)-1.1 (e f)13.4 (o)-6.1 (l)1.9 (l)-4.7 (o)4.9 (w)-8.9 (i)0.9 (n)-5.1 (g r)10.6 (e)7.2 (f 2)4.2 (. F)-9.6 (o)-4.7 (r a g)-9.4 (o)-11.8 (o)-13 (d )]TJ T* [(g)-8.3 (e)-2.1 (n)-1.1 (e)-2.1 (r)-4.7 (a)-0.8 (l o)6.2 (v)8.2 (e)-2.1 (r)-38.1 (v)-8.4 (ie)7.2 (w o)-4.7 (n c)-18.5 (a)-1.4 (r)4.4 (d)-5.8 (i)-5.3 (a)-5.6 (c r)-4.7 (a)-5.6 (d)-5.8 (i)-3.2 (o)-4.7 (n)3.3 (u)-5.4 (c)-7.4 (l)1.6 (i)-3.9 (d)-8.3 (e im)-8 (a)-6 (g)-5.8 (i)0.9 (n)-5.1 (g i)0.9 (n r)8.6 (o)-13 (d)-8.3 (e)-2.1 (n)8.2 (t)-7.1 (s)-4.6 (, )]TJ T* [(t)-1.4 (h)-1.1 (e r)10.6 (e)-8.5 (a)-5.6 (d)-8.3 (e)-2.1 (r is s)4.3 (u)-6 (g)-10.7 (g)-8.2 (e)-2.3 (s)-2.3 (t)12.4 (e)-8.7 (d t)12.5 (o s)-0.9 (e)-4.7 (e r)10.6 (e)7.2 (f)33.5 (. 3)-13.6 (.)]TJ 0 -2.271 TD [(E)-2.9 (C)-11.5 (G)-52.2 (-)-52.4 (g)-13.2 (a)1.6 (t)12.4 (e)-8.7 (d P)-12 (E)-31.9 (T a)-5.6 (c)-9.9 (q)-3.9 (u)-1 (i)-0.6 (s)0.6 (i)-2.7 (t)-0.9 (i)-3.2 (o)-4.7 (ns a)-1.4 (r)10.6 (e o)6.3 (f)-25.2 (t)12.4 (e)-2 (n r)10.6 (e)-8.7 (q)-3.9 (u)-1 (i)0.9 (r)10.6 (e)-8.7 (d t)12.5 (o i)0.9 (n)12 (v)8.2 (e)-2.3 (s)-2.3 (t)-0.9 (i)-2.7 (g)-13.2 (a)1.5 (t)12.5 (e )]TJ 0 -1.351 TD [(m)7.2 (y)7.3 (o)-10.9 (c)-18.5 (a)-1.4 (r)4.4 (d)-5.8 (i)-5.3 (a)-0.8 (l v)-8.4 (i)-5.2 (a)-6.2 (b)-4.9 (i)1.7 (l)1.6 (i)-2.7 (t)-32.4 (y)48.9 (, l)-3.1 (e)7.2 (f)-25.2 (t v)8.2 (e)-2.1 (n)8.2 (t)-1.3 (r)-6.1 (i)-2.3 (c)-3.4 (u)-0.8 (l)-7 (a)-1.4 (r \()-9.5 (L)52 (V)-53.5 (\) f)2 (u)-1.5 (n)-4.6 (c)-11.3 (t)-0.8 (i)-3.2 (o)-4.7 (n a)-1.4 (n)-4.6 (d )]TJ T* [(m)7.2 (y)7.3 (o)-10.9 (c)-18.5 (a)-1.4 (r)4.4 (d)-5.8 (i)-5.3 (a)-0.8 (l m)-2.9 (e)7.7 (t)-12.3 (a)-6.2 (b)-13 (o)-6.1 (l)1.6 (i)-2.3 (c r)-4.7 (a)1.6 (t)12.4 (e b)-4.6 (u)-4.7 (t a)-0.8 (l)-0.6 (s)-3.7 (o t)12.6 (o e)15 (x)-27.1 (t)-1.3 (r)-4.7 (a)-5.6 (c)-11.3 (t a)-5.6 (c)-9.4 (c)-3.4 (u)-1.5 (r)-4.7 (a)1.6 (t)12.4 (e a)-1.4 (r)-33.8 (t)12.4 (e)-2.1 (r)-6.1 (i)-5.3 (a)-0.8 (l )]TJ T* [(i)0.9 (n)-3 (p)-4.6 (u)-4.7 (t f)2 (u)-1.5 (n)-4.6 (c)-11.3 (t)-0.9 (i)-3.1 (o)-4.7 (n fr)8.6 (o)-5.1 (m l)-3.1 (e)7.2 (f)-25.2 (t c)-18.5 (a)-1.4 (r)4.4 (d)-5.8 (i)-5.3 (a)-5.5 (c v)8.2 (e)-2.1 (n)8.2 (t)-1.3 (r)-6.1 (i)-2.3 (c)-7.4 (l)-3.1 (e)-2.3 (s w)-9.5 (h)2.3 (i)1.7 (l)-3 (e mi)0.9 (n)2.3 (imi)5.4 (z)4.4 (i)0.9 (n)-5.1 (g )]TJ T* [(t)-1.4 (h)-1.1 (e c)-9.9 (o)-4.7 (r)-9 (r)-6.6 (u)-6.2 (p)2.5 (t)-0.9 (i)-3.1 (o)-4.7 (n b)1.5 (y m)7.2 (y)7.3 (o)-10.9 (c)-18.5 (a)-1.4 (r)4.4 (d)-5.8 (i)-5.3 (a)-0.8 (l u)-6.2 (p)2.5 (t)-12.3 (a)1.9 (k)22 (e d)-3 (u)-3.5 (e t)12.5 (o c)-18.5 (a)-1.4 (r)4.5 (d)-5.8 (i)-5.3 (a)-5.6 (c m)-5.9 (o)6.7 (t)-0.9 (i)-3.2 (o)-4.7 (n)-3 (, )]TJ T* [(s)-0.9 (e)-4.7 (e r)10.6 (e)7.2 (f)33.5 (. 4)-13.4 (.)]TJ 0 -2.271 TD [(F)-9.6 (o)-4.7 (r a g)-3.9 (u)-1 (i)-4 (d)-8.3 (e o)-4.7 (n D)-24.8 (y)-9.9 (n)-6.1 (a)-1.8 (mi)-2.3 (c im)-8 (a)-6 (g)-5.8 (i)0.9 (n)-5.1 (g w)-9 (i)-2.7 (t)-1.3 (h s)-4.6 (p)-10.1 (e)-6.6 (c)-7 (i)-5.3 (a)-0.8 (l f)13.4 (o)-10.9 (c)-3.4 (u)-2 (s o)-4.7 (n c)-18.5 (a)-1.4 (r)4.4 (d)-5.8 (i)-5.3 (a)-5.6 (c )]TJ 0.001 Tc -0.001 Tw 0 -1.351 TD [(k)-7.4 (i)1.9 (ne)8.8 (ti)-1.3 (c)1 ( an)-5.1 (al)-9 (ys)1.7 (is)1 ( se)-3.7 (e)1 ( B)-1.5 (r)-5.6 (u)2.7 (k)23 (e)-1.1 (r)-16.6 (\222)39.2 (s)1 ( n)-3 (o)7.7 (t)13.4 (e)1 ( r)11.6 (e)8.3 (f)34.5 (.)1 ( 5)-14 (.)]TJ 0 Tc 0 Tw 0 -2.271 TD [(B)-2.5 (r)-6.6 (u)1.6 (k)22 (e)-2.1 (r P)-12 (E)-31.8 (T s)-0.8 (y)-0.8 (s)-2.3 (t)12.5 (e)-2.5 (m)-1.5 (s o)6.3 (f)-25.7 (f)15.4 (e)-2.1 (r r)10.6 (e)7.7 (t)-1.3 (r)8.6 (o)-3.3 (s)-4.6 (p)-10.1 (e)-6.6 (c)-11.3 (t)-0.9 (i)-6.9 (v)8.2 (e g)-13.2 (a)1.6 (t)-0.9 (i)0.9 (n)-5.1 (g)-5.8 (. 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Bruker NMI (Nuclear Molecular Imaging). Bruker BioSpin Preclinical Imaging Division, Rudolf-Plank-Str. 23, 76275 Ettlingen, Germany 2. Biomedical MRI/ MoSAIC, KU Leuven, Leuven, Belgium Corresponding author: C Molinos cesar.molinos@bruker.com Requirement for the user The user of this guide is required to have successfully completed the Bruker training course that normally follows the scanner installation. It is also assumed for the user to be familiar with small animal handling practices, comply with the local rules on animal care as well as ionizing radiation work. Introduction Bruker offers a whole range of high performing instruments for preclinical PET cardiac imaging both as PET/CT and PET/ MR hybrid systems. A technical description on the new Bruker PET design and performance can be found in ref. 1. The impact of Bruker’s new PET technology in cardiac imaging has been discussed in the following ref 2. For a good general overview on cardiac radionuclide imaging in rodents, the reader is suggested to see ref. 3. ECG-gated PET acquisitions are often required to investigate myocardial viability, left ventricular (LV) function and myocardial metabolic rate but also to extract accurate arterial input function from left cardiac ventricles while minimizing the corruption by myocardial uptake due to cardiac motion, see ref. 4. For a guide on Dynamic imaging with special focus on cardiac kinetic analysis see Bruker’s note ref. 5. Bruker PET systems offer retrospective gating. The gating trigger is embedded on the list mode file and the data sorted into time bins right before reconstruction. In PET, this implementation is considered the most accurate and has the advantage of allowing different gate number definitions (currently 4, 8 or 16 cardiac frames) post acquisition. 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