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I)-3.2 (m)-8 (a)-6 (g)-5.8 (i)0.9 (n)-5.1 (g w)-3.3 (a)-2 (s )]TJ 0.001 Tc -0.001 Tw 0 -1.351 TD [(p)-9.1 (e)-1.1 (r)-33.3 (f)14.5 (o)-3.7 (r)-8.5 (m)-2 (e)-7.7 (d)1 ( w)-8.5 (h)3.3 (i)2.7 (l)-2 (e)1 ( an)3.3 (i)1.4 (m)-7 (al)0.5 (s)1 ( w)6.8 (e)-1.1 (r)11.6 (e)1 ( ane)-1.2 (s)-1.3 (the)8.7 (ti)6.4 (z)15 (e)-7.8 (d)1.1 ( an)-3.6 (d)1 ( p)-6.8 (l)-6 (a)-4.6 (c)-6.5 (e)-7.7 (d)1.1 ( i)2 (n)1 ( the)1 ( )]TJ 0 Tc 0 Tw 0 -1.351 TD [(p)-5.4 (r)8.6 (o)-4.7 (n)-1.1 (e p)-13 (o)-3.3 (s)0.6 (i)-2.7 (t)-0.9 (i)-3.1 (o)-4.7 (n a)1.6 (t c)-7.5 (e)-2.1 (n)8.2 (t)12.4 (e)-2.1 (r o)6.3 (f t)-1.4 (h)-1.1 (e s)-2.8 (c)-18.5 (a)-1.4 (n)1.8 (n)-1.1 (e)-2.1 (r b)-10.1 (e)-8.7 (d)-7.4 (. P)-12 (E)-31.9 (T a)-5.7 (c)-9.9 (q)-3.8 (u)-1 (i)-0.6 (s)0.6 (i)-2.7 (t)-0.9 (i)-3.2 (o)-4.7 (n )]TJ T* [(t)-0.9 (im)-3 (e)-2.3 (s w)5.8 (e)-2.1 (r)10.7 (e b)-10.1 (e)7.7 (t)-28.6 (w)5.8 (e)-4.7 (e)-2.1 (n 5)-66.4 (-)36.5 (1)38.6 (5 mi)0.9 (n)3.3 (u)-4.7 (t)12.4 (e)-2.3 (s)-4.2 (. F)-9.6 (o)-6.1 (l)1.9 (l)-4.6 (o)4.9 (w)5.8 (e)-8.7 (d b)1.5 (y P)-12 (E)-31.9 (T )]TJ T* [(s)-2.8 (c)-18.5 (a)-1.4 (n)1.8 (n)2.3 (i)0.9 (n)-5.1 (g)-12.1 (, a c)-9.9 (o)-5.1 (m)-4.9 (p)-4.6 (u)-4.7 (t)12.4 (e)-2.1 (r t)12.6 (o)-5.1 (m)-5.9 (o)-11.4 (g)-6.2 (r)-4.7 (a)-6.2 (p)-7.4 (h)9.7 (y \()-6.7 (C)-29.6 (T)-49.2 (\) o)6.3 (f t)-1.4 (h)-1.1 (e w)-9.5 (h)-4 (o)-6.1 (l)-3 (e b)-5.4 (r)-4.7 (a)-1 (i)0.9 (n )]TJ T* [(w)-3.3 (a)-2 (s p)-10.1 (e)-2.1 (r)-34.3 (f)13.4 (o)-4.7 (r)-9.5 (m)-3 (e)-8.7 (d)-7.3 (. 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T)-20.6 (h)-1 (e a)-6.2 (p)-10.2 (p)-5.4 (r)8.6 (o)-11.9 (a)-5.6 (c)-6.8 (h f)13.4 (o)-4.7 (r a)-6.2 (p)-10.2 (p)-7.8 (l)-10 (y)-7 (i)0.9 (n)-5.1 (g a)-1.4 (n a)1.6 (t)-0.9 (l)-6.9 (a)-2.1 (s t)12.5 (o s)-2.3 (t)1.9 (u)-5.4 (d)-16.6 (y )]TJ T* [(d)-13.2 (a)1.6 (t)-12.3 (a c)-18.5 (a)-1.4 (n v)-1.8 (a)-1.4 (r)-41 (y d)-8.3 (e)-6.8 (p)-10.1 (e)-2.1 (n)-4.6 (d)-5.8 (i)0.9 (n)-5.1 (g o)-4.6 (n t)-1.4 (h)-1.1 (e t)-1.3 (r)-4.7 (a)-5.6 (c)-7.5 (e)-2.1 (r a)-1.4 (n)-4.6 (d t)-1.4 (h)-1.1 (e a)-5.6 (c)-9.4 (c)-9.9 (o)-5.1 (m)-4.9 (p)-11.4 (a)-1.4 (n)9.7 (y)-7 (i)0.9 (n)-5.1 (g )]TJ 0 -1.351 TD [(a)-1.4 (n)-6.1 (a)1.6 (t)12.5 (o)-5.1 (mi)-2.3 (c)-18.5 (a)-0.8 (l m)-5.8 (o)-13 (d)-13.2 (a)-0.8 (l)1.6 (i)-2.7 (t)-32.4 (y e)-2.5 (m)-4.9 (p)-7.8 (l)-4.7 (o)3.4 (y)9.7 (e)-8.7 (d)-10.2 (, b)-4.6 (u)-4.7 (t t)-32.4 (y)-14.6 (p)-5 (i)-2.2 (c)-18.5 (a)-0.8 (l)1.9 (l)-10 (y r)10.6 (e)-8.7 (q)-3.9 (u)-1 (i)0.9 (r)10.6 (e)-2.3 (s a s)-4.6 (p)-11.4 (a)1.6 (t)-0.8 (i)-5.3 (a)-0.8 (l )]TJ 0 -1.351 TD [(r)10.6 (e)-7.1 (g)-5.8 (i)-0.6 (s)-2.3 (t)-1.3 (r)-4.7 (a)1.6 (t)-0.8 (i)-3.2 (o)-4.7 (n o)6.3 (f s)-2.3 (t)1.9 (u)-5.4 (d)-16.6 (y d)-13.2 (a)1.6 (t)-12.3 (a t)12.5 (o a t)12.4 (e)-2.5 (m)-4.9 (p)-7.8 (l)-6.9 (a)1.6 (t)12.4 (e im)-8 (a)-6 (g)-8.3 (e)3.7 (. H)-10.4 (e)-2.1 (r)10.6 (e w)5.8 (e w)-9 (i)1.8 (l)1.9 (l )]TJ 28.889 31.081 Td [(p)-5.4 (r)8.6 (o)6.2 (v)-8.4 (i)-4 (d)-8.3 (e a)-1.4 (n o)6.2 (v)8.2 (e)-2.1 (r)-38.1 (v)-8.4 (ie)7.2 (w o)6.3 (f t)-1.4 (h)-1.1 (e p)-5.4 (r)8.6 (o)-10.9 (c)-7.5 (e)-8.7 (d)-3 (u)-1.5 (r)10.6 (e)-2.3 (s f)13.4 (o)-4.7 (r a)-6.2 (p)-10.2 (p)-7.8 (l)-9.9 (y)-7 (i)0.9 (n)-5.1 (g a b)-5.4 (r)-4.7 (a)-1 (i)0.9 (n )]TJ T* [(VO)-10.3 (I a)1.6 (t)-0.9 (l)-7 (a)-2 (s u)-2 (s)0.6 (i)0.9 (n)-5 (g im)-8 (a)-6 (g)-8.3 (e)-2.3 (s a)-5.6 (c)-9.9 (q)-3.9 (u)-1 (i)0.9 (r)10.6 (e)-8.7 (d o)-4.7 (n B)-2.5 (r)-6.6 (u)1.6 (k)22 (e)-2.1 (r p)-5.4 (r)10.6 (e)-6.7 (c)-7.3 (l)1.6 (i)0.9 (n)2.3 (i)-2.3 (c)-18.5 (a)-0.8 (l P)-12 (E)-31.9 (T )]TJ 0.001 Tc -0.001 Tw 0 -1.351 TD [(i)1.4 (m)-7 (a)-5 (g)-4.8 (i)2 (n)-4.1 (g)1 ( sys)-1.3 (t)13.4 (e)-1.5 (ms)1 ( an)-3.6 (d)1 ( an)-5.1 (al)-9 (y)-25.6 (z)15 (e)-7.7 (d)1 ( u)-1 (s)1.6 (i)1.9 (n)-4.1 (g)1 ( the)1 ( P)-13.3 (M)-15.5 (O)-15.8 (D)1 ( an)-5 (al)-9 (ys)1.6 (is)1 ( )]TJ -0.011 Tc 0.011 Tw 0 -1.351 TD [(s)-14.7 (o)-4.7 (f)-36.2 (t)-39.6 (w)-14.3 (a)-12.4 (re)-7.3 (.)]TJ 0 0.446 0.736 scn /GS0 gs /T1_1 1 Tf -0.004 Tc 0.004 Tw 6.5 0 0 6.5 303.2261 264.6589 Tm (18)Tj 0 Tc 0 Tw 10 0 0 10 310.6497 262.0589 Tm [(F)-6.9 (D)-8.3 (G)1.8 (/)-2.5 (PE)-16.1 (T)75.6 (, W)-20.1 (i)-17.8 (t)-13.2 (h)-8.6 (o)-9.8 (u)-13.9 (t A)-7.5 (n)-8.6 (a)-15.4 (t)-4.8 (o)-8.4 (m)-6.5 (i)-15.4 (c)-20.7 (a)-11.3 (l I)-13.8 (m)-5.5 (a)-6 (g)-9.6 (e)]TJ 0 0 0 scn /GS1 gs /T1_0 1 Tf 9.25 0 0 9.25 303.2261 246.7242 Tm [(B)-4.7 (e)-6.6 (c)-18.5 (a)2.1 (u)-2 (s)-0.9 (e P)-12 (E)-31.9 (T im)-7.9 (a)-6.1 (g)-8.2 (e)-2.3 (s a)-0.8 (l)-4.7 (o)-4.7 (n)-1.1 (e d)-9.4 (o n)-4 (o)6.7 (t s)4.2 (u)-6.2 (p)-10.2 (p)-7.8 (l)-10 (y a)-1.4 (n)-6.1 (a)1.6 (t)12.5 (o)-5.1 (mi)-2.3 (c)-18.5 (a)-0.8 (l )]TJ T* [(i)0.9 (n)7.7 (f)13.4 (o)-4.7 (r)-9.5 (m)-8 (a)1.6 (t)-0.8 (i)-3.2 (o)-4.7 (n n)-1.1 (e)-6.6 (c)-7.5 (e)-2.3 (s)-6.1 (s)-10.8 (a)-1.4 (r)-41 (y f)13.4 (o)-4.7 (r a)-0.8 (l)1.6 (i)-2.8 (g)-6.2 (n)1.3 (m)-3 (e)-2.1 (n)8.3 (t t)12.5 (o a t)12.4 (e)-2.5 (m)-4.9 (p)-7.8 (l)-7 (a)1.6 (t)12.4 (e b)-5.4 (r)-4.7 (a)-1 (i)0.9 (n )]TJ T* [(im)-8 (a)-6 (g)-8.3 (e)5.2 (, a m)-8 (a)1.6 (t)10.6 (c)-6.9 (h)2.3 (i)1 (n)-5.1 (g C)-29.6 (T o)-4.7 (r M)-13.1 (R s)-2.3 (t)1.9 (u)-5.4 (d)-16.6 (y im)-8 (a)-6 (g)-8.3 (e i)-0.6 (s u)-2 (s)4.2 (u)-8.5 (a)-0.8 (l)1.9 (l)-10 (y u)-2 (s)-0.9 (e)-8.7 (d )]TJ T* [(a)-2 (s a)-1.4 (n i)0.9 (n)8.2 (t)12.4 (e)-2.1 (r)-9.5 (m)-2.9 (e)-8.8 (d)-5.7 (i)-5.3 (a)-1.4 (r)-41 (y t)12.5 (o a)-0.8 (l)1.6 (i)-2.8 (g)-6.2 (n d)-13.2 (a)1.6 (t)-12.3 (a)-3.7 (. H)-11.7 (o)4.9 (w)5.8 (e)8.6 (v)8.2 (e)-2.1 (r)49.8 (, H)-15.6 (a)-1.4 (r)4.4 (d)-8.3 (e)-2.1 (r)-6.1 (i)-5.3 (a)-1.4 (n g)-5.6 (l)-7 (a)-1.4 (n)-4.6 (d)-6.8 (s )]TJ 0 -1.351 TD [(p)-5.4 (r)8.6 (o)6.2 (v)-8.4 (i)-4 (d)-8.3 (e a d)-5.8 (i)-0.6 (s)-2.3 (t)-0.8 (i)0.9 (n)-4.6 (c)-11.3 (t s)-4.6 (p)-11.4 (a)1.6 (t)-0.9 (i)-5.3 (a)-0.8 (l a)-1.4 (n)-6.1 (a)1.6 (t)12.5 (o)-5.1 (mi)-2.2 (c)-18.5 (a)-0.8 (l l)-7 (a)-1.4 (n)-4.6 (d)-6.7 (m)-8 (a)-1.4 (r)-3.7 (k i)0.9 (n )]TJ -0.012 Tc 0.012 Tw 6.0125 0 0 6.0125 502.1073 199.1292 Tm (18)Tj 0.008 Tc -0.008 Tw 9.25 0 0 9.25 508.9922 196.7242 Tm [(FD)-8.2 (G)-20.6 (/)]TJ 0 Tc 0 Tw -22.245 -1.351 Td [(P)-12 (E)-31.9 (T im)-8 (a)-6 (g)-8.3 (e)-2.3 (s s)4.2 (u)-1 (i)-2.6 (t)-12.3 (a)-6.2 (b)-7.8 (l)-3.1 (e f)13.4 (o)-4.7 (r r)10.6 (e)-7.1 (g)-5.8 (i)-0.6 (s)-2.3 (t)-1.3 (r)-4.6 (a)1.5 (t)-0.8 (i)-3.2 (o)-4.7 (n)-2.2 (. \()-10 (H)-15.6 (a)-1.4 (r)4.4 (d)-8.3 (e)-2.1 (r)-6.1 (i)-5.3 (a)-1.4 (n g)-5.6 (l)-6.9 (a)-1.5 (n)-4.6 (d)-6.8 (s a)-1.4 (r)10.6 (e )]TJ 0 -1.351 TD [(m)-3 (e)7.7 (t)-12.3 (a)-6.2 (b)-13 (o)-6.1 (l)1.6 (i)-2.3 (c)-18.4 (a)-0.9 (l)2 (l)-10 (y a)-5.6 (c)-11.3 (t)-0.9 (i)-7 (v)8.2 (e g)-5.6 (l)-7 (a)-1.4 (n)-4.6 (d)-6.8 (s p)-5.4 (r)10.6 (e)-2.3 (s)-0.9 (e)-2.1 (n)8.2 (t i)1 (n t)-1.4 (h)-1.1 (e o)-4.7 (r)-11.4 (b)-4.9 (i)-2.7 (t o)6.3 (f c)-7.5 (e)-2.1 (r)-33.8 (t)-12.3 (a)-1 (i)1 (n )]TJ T* [(a)-1.4 (n)2.3 (im)-8 (a)-0.8 (l)-0.6 (s i)1 (n)-4.7 (c)-7.3 (l)2 (u)-5.4 (d)-5.8 (i)0.9 (n)-5.1 (g mi)-2.3 (c)-7.5 (e a)-1.4 (n)-4.6 (d r)-4.7 (a)1.6 (t)-7.1 (s)7.3 (\))22.9 (. )]TJ -0.012 Tc 0.012 Tw 6.0125 0 0 6.0125 439.6993 161.6292 Tm (18)Tj 0 Tc 0 Tw 9.25 0 0 9.25 446.5842 159.2242 Tm [(F)-8.1 (D)-16.2 (G)-28.6 (/)-39.6 (P)-12 (E)-31.9 (T s)-2.3 (t)2 (u)-5.4 (d)-16.6 (y d)-13.2 (a)1.6 (t)-12.3 (a )]TJ -15.498 -1.351 Td [(c)-18.5 (a)-1.4 (n b)-10.1 (e a)-0.8 (l)1.6 (i)-2.8 (g)-6.2 (n)-1.1 (e)-8.7 (d t)12.6 (o a)-1.4 (n )]TJ -0.012 Tc 0.012 Tw 6.0125 0 0 6.0125 388.3987 149.1292 Tm (18)Tj 0 Tc 0 Tw 9.25 0 0 9.25 395.2836 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)]TJ -0.012 Tc 0.012 Tw 6.0125 0 0 6.0125 407.954 111.6292 Tm (18)Tj 0 Tc 0 Tw 9.25 0 0 9.25 414.8389 109.2242 Tm [(F)-8.1 (D)-16.2 (G)-28.6 (/)-39.6 (P)-12 (E)-31.9 (T s)-2.3 (t)2 (u)-5.4 (d)-16.6 (y d)-13.2 (a)1.6 (t)-12.3 (a a)-1.4 (r)10.6 (e s)0.8 (h)-4 (o)4.9 (w)-11.8 (n )]TJ -12.066 -1.351 Td [(b)-10.1 (e)-1.8 (l)-4.7 (o)4.9 (w u)-2 (s)0.6 (i)0.9 (n)-5.1 (g a t)-32.3 (y)-14.8 (p)-4.8 (i)-2.3 (c)-18.5 (a)-0.8 (l d)-13.2 (a)1.6 (t)-12.3 (a)-2 (s)-0.9 (e)7.7 (t a)-5.6 (c)-9.9 (q)-3.9 (u)-1 (i)0.9 (r)10.6 (e)-8.7 (d w)-9 (i)-2.6 (t)-1.4 (h t)-1.4 (h)-1.1 (e B)-2.5 (r)-6.6 (u)1.6 (k)22 (e)-2.1 (r )]TJ T* [(A)-23.4 (l)-4.2 (b)-4.9 (i)0.9 (r)-4.6 (a S)-6.9 (i P)-12 (E)-31.9 (T s)-0.8 (y)-0.8 (s)-2.3 (t)12.4 (e)-2.5 (m a)-1.4 (n)-4.6 (d a)-1.4 (n)-6.1 (a)-0.8 (l)-10 (y)-26.6 (z)13.9 (e)-8.7 (d u)-2 (s)0.7 (i)0.9 (n)-5.1 (g t)-1.4 (h)-1.1 (e M)-14.2 (o)-4 (u)-2 (s)-0.9 (e M)-14.2 (. )]TJ T* [(M)-8.8 (i)0.9 (r)-9 (r)8.7 (o)-4.8 (n)-1.1 (e a)1.6 (t)-0.8 (l)-7 (a)-2 (s \()-10.9 (M)-18 (a e)7.7 (t a)-0.8 (l.)11 (, 2)-10.1 (0)-41.7 (0)-31.1 (5)-11.4 (\) i)0.9 (n)-4.6 (c)-7.3 (l)2 (u)-5.4 (d)-8.3 (e)-8.7 (d i)0.9 (n w)-9 (i)-2.7 (t)-1.4 (h t)-1.4 (h)-1.1 (e P)-14.3 (M)-16.4 (O)-16.8 (D )]TJ T* [(a)-1.4 (n)-6.1 (a)-0.8 (l)-10 (y)-0.8 (s)0.6 (i)-0.6 (s s)-3.7 (o)6.3 (f)-25.2 (t)-28.6 (w)-3.2 (a)-1.4 (r)10.6 (e \()-52 (V 3)-13.6 (.)-21.1 (9)-5.5 (, P)-14.3 (M)-16.5 (O)-16.8 (D T)62.9 (e)-6.6 (c)-6.8 (h)1.8 (n)-4 (o)-6.1 (l)-4.6 (o)-11.4 (g)-5.8 (ie)-2.3 (s L)-15.8 (L)8.1 (C)-16.3 (, Z)0.9 (u)-1.5 (r)-6.1 (i)-2.3 (c)-6.8 (h )]TJ -0.023 Tc 0.023 Tw 0 -1.351 TD [(S)-21 (w)-32 (i)-25.6 (t)-43.4 (z)-9.1 (e)-25.1 (r)-29.1 (l)-30 (a)-24.4 (n)-27.6 (d)-33.9 (\).)-22.9 ( )]TJ ET 0 0.446 0.736 scn /GS0 gs 0.125 665.308 595.15 11.339 re f /PlacedGraphic BMC EMC q 461.035 702.583 99.212 52.283 re W n 0 0 0 scn q 1 0 0 1 461.6702 723.0244 cm 0 0 m 0 11.505 l 12.147 11.505 l 13.269 11.505 13.75 10.959 v 14.231 10.414 14.365 9.847 14.397 9.109 c 14.429 8.372 14.135 7.618 13.713 7.185 c 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"a*|&ܷOnGޝ?+L!kRj`H=BTe*Fa cEg.X7\`s߁A0,0"2ale©0Ia?p_bH3/^;œ :=wߣpFƌUBRa,q|<)ūg;Όd7Rtkhe-zO-Ͷυ ,/_,E eH3ß8( /U1O|,8C+%Z}M8@aYFCg 82W(bgV%|qyu0-T2"nweyZ"ZkX_aN[} >?W皎kԿ[6Jmry̚H/llޤдD8x0]dEM5?Pe 22Vd.G!(fu77YFk SUBkVE ">bt -1_!6\e5/]6y:!&g"=L-J~ Yot-$=r23GT ߖF)J` )aH&۬@e\ɞ-iZL˗Cr*niv ~w!I)@3k]"H0oI Lro}4cz>VN{ٷDlS]xr_Pa"E ~W{ ",NA<ȴ4-w5cnr$`-o ZhFmZ~OT^Y -=s Jܐ qQ9.e0E}ig6AYv4i s0Ԕx}^.։t ׀$*0bihի,> endobj xref 0 105 0000000000 65535 f 0000000016 00000 n 0000000124 00000 n 0000002752 00000 n 0000000000 00000 f 0000002848 00000 n 0000003256 00000 n 0000003672 00000 n 0000004117 00000 n 0000004534 00000 n 0000004963 00000 n 0000005393 00000 n 0000005790 00000 n 0000607792 00000 n 0000630980 00000 n 0000039047 00000 n 0000038823 00000 n 0000038936 00000 n 0000019986 00000 n 0000020755 00000 n 0000651939 00000 n 0000631037 00000 n 0000503262 00000 n 0000517771 00000 n 0000543975 00000 n 0000550647 00000 n 0000555741 00000 n 0000416533 00000 n 0000496097 00000 n 0000427242 00000 n 0000436824 00000 n 0000441785 00000 n 0000450353 00000 n 0000458081 00000 n 0000304100 00000 n 0000400759 00000 n 0000323652 00000 n 0000355491 00000 n 0000362043 00000 n 0000222045 00000 n 0000230393 00000 n 0000230450 00000 n 0000255482 00000 n 0000275940 00000 n 0000278366 00000 n 0000121071 00000 n 0000128665 00000 n 0000128722 00000 n 0000137434 00000 n 0000146892 00000 n 0000200884 00000 n 0000041731 00000 n 0000042947 00000 n 0000043004 00000 n 0000006156 00000 n 0000019856 00000 n 0000033578 00000 n 0000033603 00000 n 0000026867 00000 n 0000026961 00000 n 0000027585 00000 n 0000021225 00000 n 0000021688 00000 n 0000022238 00000 n 0000028267 00000 n 0000033910 00000 n 0000034077 00000 n 0000034146 00000 n 0000034405 00000 n 0000034490 00000 n 0000039082 00000 n 0000118901 00000 n 0000220656 00000 n 0000219267 00000 n 0000216087 00000 n 0000215358 00000 n 0000302551 00000 n 0000300924 00000 n 0000299535 00000 n 0000297908 00000 n 0000399132 00000 n 0000397505 00000 n 0000395878 00000 n 0000400898 00000 n 0000400923 00000 n 0000401223 00000 n 0000401393 00000 n 0000401462 00000 n 0000401742 00000 n 0000401826 00000 n 0000501397 00000 n 0000500008 00000 n 0000498381 00000 n 0000496142 00000 n 0000494470 00000 n 0000497769 00000 n 0000606165 00000 n 0000604538 00000 n 0000603149 00000 n 0000601522 00000 n 0000650654 00000 n 0000652415 00000 n 0000652898 00000 n 0000653455 00000 n 0000657479 00000 n trailer <<1334C6A9DD8F7A45B082CC31CA7E5624>]>> startxref 657663 %%EOF %BeginExifToolUpdate 104 0 obj << /CreationDate (D:20180402163007-04'00') /Creator (Adobe InDesign CC 2017 \(Windows\)) /ModDate (D:20180402163008-04'00') /Producer (Adobe PDF Library 15.0) /Trapped /False /Author (Adobe InDesign CC 2017 \(Windows\)) >> endobj 2 0 obj << /Type /Metadata /Subtype /XML /Length 7091 >> stream Adobe InDesign CC 2017 (Windows) nullPreclinical NeuroPET is employed widely in studies of stroke, ischemia, addiction and neurodegenerative diseases. A wide range of tracers are used in NeuroPET studies. In both clinical and preclinical imaging, 18FDG is frequently used as a biomarker of brain function in models of neurological disorders (Balsara et al., 2014, Sobrado et al., 2011, Pozo et al., 2008). Targeted tracers such as the recently FDA approved Florbetapir F18 (AMYViD) amyloid tracer provide specific activity (Bonet-Costa et al., 2015). Additionally, using both post synaptic and pre synaptic specific tracers, researchers can make in vivo measurements of neurotransmitter function. To facilitate the analysis of preclinical NeuroPET data, several rat and mouse brain VOI (volume-of-interest) atlases have been developed and are available for use today. A brain atlas consists of a set of VOIs (outlining brain regions) and requires a template brain image for processing. The template mouse or rat brain may be based on an image derived from a single mouse or rat image or an average of multiple mouse or rat brain images. The approach for applying an atlas to study data can vary depending on the tracer and the accompanying anatomical modality employed, but typically requires a spatial registration of study data to a template image. Here we will provide an overview of the procedures for applying a brain VOI atlas using images acquired on Bruker preclinical PET imaging systems and analyzed using the PMOD analysis software. 18FDG/PET, Without Anatomical Image Because PET images alone do not supply anatomical information necessary for alignment to a template brain image, a matching CT or MR study image is usually used as an intermediary to align data. However, Harderian glands provide a distinct spatial anatomical landmark in 18FDG/ PET images suitable for registration. (Harderian glands are metabolically active glands present in the orbit of certain animals including mice and rats). 18FDG/PET study data can be aligne application/pdf Adobe InDesign CC 2017 (Windows) Adobe PDF Library 15.0 False 2018-04-02T16:30:07-04:00 Adobe InDesign CC 2017 (Windows) 2018-04-02T16:30:08-04:00 2018-04-02T16:30:08-04:00 xmp.did:ca236cd1-b4b8-f647-a49e-cfe317b8c7e7 xmp.iid:94d5e959-8cd0-4346-af70-1580e04b9ee7 adobe:docid:indd:7a04b3ea-bcc1-11df-b375-80f766f0bf51 default 1 xmp.id:f2527e91-ec5f-ea45-ad07-a56b6ff0ad9f converted / from application/x-indesign to application/pdf Adobe InDesign CC 2017 (Windows) 2018-04-02T16:30:07-04:00 uuid:4685e56c-b5ca-4901-812e-3b1f0d3e37a7 adobe:docid:indd:7a04b3ea-bcc1-11df-b375-80f766f0bf51 proof:pdf endstream endobj xref 0 1 0000000000 65535 f 2 1 0000660195 00000 n 104 1 0000659945 00000 n trailer << /Size 105 /Root 1 0 R /Info 104 0 R /ID [ <1534C6A9DD8F7A45B082CC31CA7E5624> ] /Prev 657663 >> %EndExifToolUpdate 659923 startxref 667378 %%EOF